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Background: Alcohol abuse is on increasing trend in world as well as in India, especially in young population. Long-term alcohol intake may leads to alcoholic chronic liver disease which may turns in to end stage liver diseases. Alcoholic chronic liver disease is associated with some hematological abnormalities which if detected at early stage may provide clear therapeutic implications in managing these patients and reducing the adverse events. Aims and Objectives: Our aim of the study was to identify various hematological abnormalities in patients of alcoholic chronic liver disease. Materials and Methods: This hospital-based cross-sectional study includes 100 randomly selected patients with alcoholic chronic liver disease attending Out-Patient Department and admitted in General Medicine ward of Burdwan Medical College satisfying the inclusion and exclusion criteria. Data were analyzed for hemoglobin (Hb), red blood cell (RBC), total leukocyte count (TLC), platelet count, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), MCH concentration, and prothrombin time-international normalized ratio. The mean and standard deviation, percentages, and ratio were calculated and presented in the form of tables with the help of SPSS (IBM) ver-23. P < 0.05 was considered statistically significant. Results: Hematological abnormalities were found more with increased duration of alcohol consumption. Prolonged bleeding time was observed in 23% cases and prolonged clotting time was observed in 21% cases. Maximum patients belonged to Child–Pugh grade C. Hematological abnormalities were more in patients belonging to Child–Pugh grade C. Hb, RBC, platelet, and packed cell volume were significantly lower in patients belonging to Child–Pugh class C, whereas TLC, MCV, and MCH were significantly higher in class C. Conclusion: It can be concluded that related hematological changes, which are common in alcoholic chronic liver disease endanger the lives of these patients. They should be detected and corrected at earliest to minimize morbidity and mortality.
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Non-alcoholic Fatty Liver Disease (NAFLD) is a distinct hepatic condition and one of the most common causes of Chronic Liver Disease globally. In February, 2021, the Government of India had launched and integrated interventions to prevent and control NAFLD in the ongoing National Programme for Prevention & Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS). This review was conducted to identify challenges and proposes solutions for effective program implementation. The authors identified that since NPCDCS has been implemented as District-based program and NAFLD being new component, the lack of familiarity of various sub-group of staff could be a major challenge in roll-out. The sensitization of Health Workers, Medical Officer in Primary Healthcare System, the specialist doctors at all levels of care as well as private practitioners, on various aspects of NAFLD (including epidemiology, clinical features, treatment approach and other aspects) should be conducted. The Information Education Communication (IEC) material should be developed and campaigns for awareness generation amongst general public in prevention and management of the disease should be conducted.Ongoing activities to set up Health and Wellness Centres under Ayushman Bharat Program, is a good opportunity to integrate of NAFLD in primary care level. This will help India to accelerate progress towards Universal Health Coverage
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The incidence of colorectal cancer (CRC) is increasing rapidly in China. In fact, in 2019, China was the country with the highest CRC case numbers in the world. Specific myeloid cell subsets are recruited into the liver micro-environment via chemokine-receptor axis and facilitate the progression of colorectal liver metastasis(CRLM). In China, many CRC patients suffer concomitant chronic liver diseases, such as chronic hepatitis B (CHB), nonalcoholic fatty liver disease (NAFLD), and alcoholic liver disease (ALD). Aberrant expression of chemokines is observed in these chronic liver diseases, and some of them have been associated with cancer metastasis. Here, first, we review the recent epidemiological trends of CRC, CHB, NAFLD, and ALD in China, briefly summarizing the abnormal chemokine changes in these chronic liver diseases. Furthermore, we review the potential mechanisms that may explain how different chronic liver diseases facilitate CRLM, focusing on the chemokine-myeloid cell subsets axis, which has been previously reported to be related to CRLM.
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Background/objectives: The area of hypercoagulability in cirrhosis and its potential contribution to certain clinical aspects have received a lot of attention. The clinical manifestations of the hemostatic disorders of cirrhosis have been traditionally related to bleeding due to multiple procoagulant factor defects, excessive fibrinolysis, and thrombocytopenia. Aim: Assess the function of blood coagulation in patients with chronic liver diseases and improve the knowledge of the pathophysiology of haemostasis. Patients and methods: This is a prospective case-control study which was conducted at outpatient clinic of internal medicine dept., Minia University Hospital, Minia Governorate, during the period from March 2017 to August 2018. Results: Protein C and S concentrations decreased significantly in Group (II A, II B, and IIC) compared to control and also, Group (II C) decreased significantly than Group (II A, II B). Regarding Thrombin fragments (F 1+2), Child score A patients had significantly higher concentration compared to the other three groups. However, as regards, Thrombin-antithrombin (TAT), Child score C group had a significantly higher level compared to other groups. Conclusion: Thrombin fragments and thrombin antithrombin complex are considered as the main specific markers for thrombin generations which were elevated strongly depending upon the pathogenesis and the severity of the liver diseases.
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Objectives:Renal impairment in Patients with chronic liver disease is a common phenomenon and is a functional impairment. It seems difficult for the assessment of renal function abnormalities by normal parameters. We aimed to determine the usefulness of creatinine clearance by timed urine collection and Cockcroft Gault formula and Serum creatinine as parameters in assessing renal function in this cohort of patients and also to find if etiology of chronic liver disease has a bearing on renal dysfunction. Material and methods:Renal parameters of 200 patients with chronic liver disease were studied to assess the reliability of the each parameter. Results: In the present study, Only 22% of alcoholics have clearance more than 60ml/min. 58% patients were found to have creatinine clearance more than 60ml/min by Cockcroft Gault formula while only 36% Patients have that by timed urine collection where the difference was found to be statistically significant (Pvalue<0.01). Cockcroft Gault formula overestimates probably due to disparity in weight due to fluid retention. Conclusion:ThemostreliableParameterin our clinicalsetup isCreatinine clearance by timed urine collection.Presence ofAscites,lowserumalbumin levels andAlcoholic etiologyhadmorepredispositiontorenalimpairment,however, a largerstudywithmorenumber ofpatients canthrowmore ligh
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In recent years, extracellular vesicles are found as an important medium for intercellular signal communication in prokaryotic and higher eukaryotic cells for regulating a variety of biological processes.Extracellular vesi-cles include exosomes,microvesicles and apoptotic bodies,and can be released into extracellular media by almost all types of cells in vivo and in vitro.Extracellular vesicles are released under physiological and pathological conditions, including liver diseases,and have a wide range of effects on the target cells.This review summarizes the progress in understanding the role of extracellular vesicles in chronic liver diseases.Specifically, how extracellular vesicles regulate non-alcoholic steatohepatitis,alcoholic liver disease, viral hepatitis, liver fibrosis and hepatocellular carcinoma is discussed in detail highlighting extracellular vesicles as a promising therapeutic target for chronic liver diseases.
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Stem cell has been one of the focuses in current biomedical research. It has been well documented that there are various liver stem cells (LSCs) with different markers in liver, and they play important roles in liver regeneration. Moreover, some progresses have been made in autologous and allogeneic stem cells transplantation for the treatment of end-stage liver diseases. However, the origin and markers of LSCs have not been fully clarified, and the mechanism involved in LSCs proliferation and differentiation remains to be deeply studied. With the improvements of lineage tracing technique and stem cell isolation and culture system, it is believed that the origin of LSCs and their role in liver regeneration will be further clarified, and LSCs treatment for liver diseases will soon become a reality.
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Based on their ability to differentiate into multiple cell types including hepatocytes, the transplantation of mesenchymal stem cells (MSCs) has been suggested as an effective therapy for chronic liver diseases. The aim of this study was to evaluate the safety, efficacy and therapeutic effects of MSCs in patients with chronic liver disease through a literature-based examination. We performed a systematic review (SR) and meta-analysis (MA) of the literature using the Ovid-MEDLINE, EMBASE and Cochrane Library databases (up to November 2014) to identify clinical studies in which patients with liver diseases were treated with MSC therapy. Of the 568 studies identified by the initial literature search, we analyzed 14 studies and 448 patients based on our selection criteria. None of the studies reported the occurrence of statistically significant adverse events, side effects or complications. The majority of the analyzed studies showed improvements in liver function, ascites and encephalopathy. In particular, an MA showed that MSC therapy improved the total bilirubin level, the serum albumin level and the Model for End-stage Liver Disease (MELD) score after MSC treatment. Based on these results, MSC transplantation is considered to be safe for the treatment of chronic liver disease. However, although MSCs are potential therapeutic agents that may improve liver function, in order to obtain meaningful insights into their clinical efficacy, further robust clinical studies must be conducted to evaluate the clinical outcomes, such as histological improvement, increased survival and reduced liver-related complications, in patients with chronic liver disease.
Subject(s)
Humans , Cell Differentiation/physiology , Cell- and Tissue-Based Therapy/adverse effects , Hepatocytes/cytology , Liver/physiopathology , Liver Diseases/therapy , Liver Function Tests , Mesenchymal Stem Cell Transplantation/adverse effects , Mesenchymal Stem Cells/cytologyABSTRACT
This study was aimed to establish an objective and quantitative index system and standards of diag-nosis and treatment on the syndrome of liver-kidney essence deficiency for chronic liver diseases , in order to improve the level of diagnosis and treatment , clinical efficacy and service capabilities in the prevention and treatment of chronic liver diseases in traditional Chinese medicine ( TCM ) . Modern biological indicators of liver damage and liver regeneration were used as objective and quantitative indicators to study the syndrome of liv-er-kidney essence deficiency . And the syndrome of liver-kidney essence deficiency , which was used to be considered as a recessive syndrome, was finally turning into a dominant syndrome . Hence , the symptom i-dentification can be accurate . The establishment of an objective and quantitative index system and standards of diagnosis and treatment of liver-kidney essence deficiency , which was based on biological indicators such as indicators of histological damage in liver , indicators of hypohepatia , indicators of aregeneratory and indicators of liver dysfunction . According to all indicators , a dynamic monitoring was given on the development law of the syndrome of liver-kidney essence deficiency . All indicators provided references for the prognosis determina-tion and syndrome differentiation . It was concluded that the objective and quantitative research on the syn-drome of liver-kidney essence deficiency in chronic liver diseases is an effective way to improve the level of diagnosis and treatment, clinical efficacy and service capabilities in the prevention and treatment of chronic liver diseases in TCM , which is worth further study .
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Objective To investigate the liver function of patients with chronic liver diseases undergoing gynecologic laparoscopic operations.Methods Twenty-six asymptomatic HBV carriers,28 mild chronic hepatitis,21 compensatory cirrhosis were assigned to undergo gynecologic laparoscopic operations.Liver function were tested and compared in these three groups before operation and on the 1st、3rd、7th day after operation.Results 1st day after operation,ALT and AST in asymptomatic carriers and mild chronic hepatitis groups were significantly higher than preoperation ( asymptomatic carriers:ALT P ＜ 0.05,AST P ＜ 0.05 ; mild chronic hepatitis:ALT P ＜ 0.05,AST P ＜ 0.05 ).Then they recovered on the 3rd day after operation ( asymptomatic carriers:ALT P ＞ 0.05,AST P ＞ 0.05 ; mild chronic hepatitis:ALT P ＞ 0.05,AST P ＞ 0.05 ).ALB,total bilirubin (Tbil) after operation were not significantly different from those before operation on every tested day in these two groups ( asymptomatic carriers:ALB P ＞ 0.05,Tbil P ＞ 0.05 ; mild chronic hepatitis:ALB P ＞ 0.05,Tbil P ＞ 0.05 ).In compensatory cirrhosis group,ALT,AST,Tbil were significantly higher on the 1st day,3rd day after operation than preoperation ( 1st day:ALT P ＜0.01,AST P ＜0.01,Tbil P ＜0.01 ;3rd day:ALT P ＜ 0.05,AST P ＜ 0.05,Tbil P ＜ 0.05 ).ALB levels were significantly lower on the 1st day,3rd day after operation than preoperation ( 1st day:P ＜0.01 ;3rd day:P ＜0.05 ).All the indexes recovered to the levels of preoperation on the 7th day after operation( ALT P ＞ 0.05,AST P ＞ 0.05,Tbil P ＞ 0.05,ALB P ＞0.05).Conclusions To some extent,gynecologic laparoscopic operations have some adverse effects on short-term liver function after operation in patients with chronic liver diseases.Compensatory cirrhosis patients present delayed recovery compared with asymptomatic carriers and mild chronic hepatitis patients.
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El ultrasonido continúa siendo la primera investigación imaginológica en el estudio de los pacientes con hepatopatías crónicas, pues le permite al médico de asistencia, de manera rápida y eficaz, conocer el estado morfológico de los órganos involucrados y, además, mediante el estudio Doppler, valorar las características del flujo del sistema portal desde el punto de vista cuantitativo (velocidad del flujo) y cualitativo (permeabilidad y dirección del flujo así como la presencia de vasos de circulación colateral). Permite también evaluar todas las estructuras de la cavidad abdominal e investigar patologías asociadas, como es el caso del síndrome hepatorrenal. A favor de esta técnica están además; su bajo costo, fácil manejo, reproductibilidad y ausencia de intervensionismo, todo ello con alta sensibilidad y especificidad, superiores al de otras técnicas complejas de diagnóstico por imagen, como es la tomografía axial computarizada o la resonancia magnética nuclear. Con este trabajo nos proponemos realizar una revisión del tema y mostrar, mediante la literatura consultada y los resultados de nuestra experiencia, el valor del ultrasonido Doppler en el estudio de los pacientes con hepatopatías crónicas
Ultrasound (US) still is the first imaging research in the study of patients presenting with chronic liver diseases allowing to assistance physician to know in a fast and effective way the morphologic state of involved organs and also, be Doppler study, to evaluate the features of portal system flow from the quantitative point of view (flow speed) and the qualitative one (flow permeability and direction as well as the presence of collateral circulation vessels). Also allows to assess the structures of the abdominal cavity and to investigate the associated pathologies such as the hepatorenal syndrome. Favoring this technique are the following: its low cost, easy management, reproducibility and lack of interventions with a high sensitivity and specificity level superior to that of other complex techniques of imaging diagnosis by example, the computerized axial tomography (CAT) or the nuclear magnetic resonance (MNR)
Subject(s)
Humans , Liver Diseases , Ultrasonography, Doppler , Ultrasonography, Doppler, Color , Diagnostic Techniques and ProceduresABSTRACT
Neijing was a early medical classic existing in China and had a deep influence on the formation of traditional Chinese medicine. Besides, Neijing was also an ancient philosophic works, in which the severe view of heaven was recorded, laying a sound basis for the development of TCM. It would have great significance for health cultivation of patients with chronic liver diseases to analyze the theory on relation between human and nature recorded in Neijing and to absorb its rational contents.
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BACKGROUND: TT virus (TTV), isolated initially from a Japanese patient with posttransfusion hepatitis of unknown etiology, was suggested to be a new causative agent of hepatitis. However, it has been found to infect both healthy and diseased individuals and numerous studies have raised questions about its pathogenic role in hepatitis. In order to study its prevalence and clinical impact on hepatitis, we assessed the frequency of TTV DNA. METHODS: Serum samples were obtained from 60 cases of the controls, 77 cases of chronic liver diseases, 44 cases of hemodialyzed patients, and 65 cases of transfused patients. TTV DNA was detected using nested polymerase chain reaction and alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatitis B surface antigen (HBsAg) were measured. RESULTS: TTV DNA was detected in 41.7% of the controls, 51.9% of patients with chronic liver diseases, 68.2% of hemodialyzed patients and 61.5% of transfused patients. Comparison between patients with or without TTV revealed no significant differences in AST, ALT, and HBsAg test results. CONCLUSION: The prevalance of TTV infection in patients with chronic liver diseases was similar to that in the controls. TTV infection was not related to abnormal liver function findings and HBsAg positivity. We found no relationship between TTV infection and chronic liver diseases.
Subject(s)
Humans , Alanine Transaminase , Asian People , Aspartate Aminotransferases , DNA , Hepatitis , Hepatitis B Surface Antigens , Liver Diseases , Liver , Polymerase Chain Reaction , Prevalence , Renal Dialysis , Torque teno virusABSTRACT
In Korea, most of the patients with chronic liver diseases have been using some kind of alternative therapies at home. however, the question is why do people turn to alternative therapy and how the patients are able to use the alternative therapies widely, though the effects have not been proven scientifically. Therefore, it is necessary to explore the process of the patients' experiences using the alternative therapies. The 16 participants were from internal- medical departments in hospital and the permission was received to participate in this study from the subjects. The data were collected with interviews and participants observations, analyzed by the grounded theory methodology of Strauss and Corbin(1990). With the analysis of the data, 15 categories were generated such as psychological pressures, barriers of role performances, distrusts of western medicine, blind obediences to the treatments, attitudes towards alternative therapies, supportive systems, obstacles to taking alternative therapies, financial burdens, collecting informations, pursuing alternative modalities, efforting diversities, analyzing by themselves, managing the body, accepting the disease, and ambivalence. The paradigm model was developed to identify the relationships of categories. The central phenomenon of the experiences of seeking alternative therapies was named jagi momdasrim. The central concept of jagi momdasrim is a mind-set to desire to wellness and to take more responsibility for one's own healing by pursuing alternate healing modalities rather than the western medical system. The process of jagi momdasrim evolved several stages such as seeking, finding, struggling, overcoming, fulfilling, and governing the diseases. Four patterns of taking alternative therapies were found as follows: the bulsin-chujong-hyung, the suyoung-hyung, the yangdari-gulchiki-hyung, the chamjae-hyung. In conclusion, the phenomenon of alternative therapies as consumer-driven force to heal the chronic liver diseases of the patients could be explained as an adaptive behavior through the process of jagi momdasrim. However, since most of the participants practicing some kind of alternative therapies had no evidences of its effects and never tried to consult with their medical doctors about alternative therapies, we should approach more actively. Therefore, it is recommended for nurses to listen and watch the patients behaviors of using alternative therapies and find out how to educate the patients about the proper and safe way to take the alternative therapies.
Subject(s)
Humans , Adaptation, Psychological , Complementary Therapies , Korea , Liver Diseases , LiverABSTRACT
BACKGROUND/AIMS: Transforming growth factor-a(TGF-a) is a polypeptide cytokine related to cell proliferation and transformation. TGF-a binds to EGF receptor and stimulating DNA synthesis in liver cell. The hepatitis B virus (HBV) by itself is also believed to play a role in the hepatic carcinogenesis. Recently, it was reported that TGF-a and HBV were synergistic in action with rapid appearance of hepatocelluar carcinoma in bitransgenic mice. Although TGF- a is thought to play an important role in hepatocarcinogenesis, its expression during the natural history of HBV hepatitis was poorly understood. This investigation was performed to elucidate the dynamic changes and istinct immunohistochemical staining patterns in the course of chronic HBV hepatitis with specific reference to hepatocelluar carcinoma and to explain the role of TGF-a in the pathogenesis of hepatocelluar carcinoma. MATERIALS/METHODS: Employing TGF-a monoclonal antibody, signal detection was carried out by peroxidase-conjugated streptavidin in deparaffinized liver tissue sections taken from HBsAg positive patients. All of the liver tissue sections were proven HBV DNA positive by in situ hybridization. Immunohistochemical staining was performed in the tissue sections obtained from four normal controls, six from patients with chronic persistent hepatitis, five with chronic active hepatitis, eight with liver cirrhosis and eleven with hepatocellular carcinoma. RESULTS: The patterns of TGF-a immunoreactivity were cytoplasmic-grain types in normal controls and chronic persistent hepatitis, honeycomb types in chronic active hepatitis, occasional cytoplasmic-flooding types in liver cirrhosis, and cytoplasmic-grape types in hepatocellular carcinoma. A Shapiro-Wilk W test for frequency table analysis for the expression of TGF-a in these different disease groups was statistically significant. CONCLUSION: These data suggest that step-wise distinct expression of TGF-a enhancement in HBV associated chranic liver diseases which eventually resulted in the development of hepatocellular carcinoma were conceivably due to dysregulation of liver cell cycles by both HBV and TGF-a during the persistent repetition of cell cycles.
Subject(s)
Animals , Humans , Mice , Carcinogenesis , Carcinoma, Hepatocellular , Cell Cycle , Cell Proliferation , DNA , Hepatitis , Hepatitis B Surface Antigens , Hepatitis B virus , Hepatitis, Chronic , In Situ Hybridization , Liver Cirrhosis , Liver Diseases , Liver , Natural History , ErbB Receptors , StreptavidinABSTRACT
BACKGROUND: Liver fibrosis by the progression of the chronic processes of the liver diseases induces deforrned microcirculations of the hepatic lobules. And this eventually resolted in portal hypertension. On the other hands, angiogenic stimu4nt factors are physiologically activated in order to repair the tissue damage. Overexpression of angiogenic factors, however, can stimulate neovascularization as in a fonnation of the tumor that liberates uncontrolled overgrowing of the tumor cells. METHODS: To elucidate the dynamic changes of the serum concentration of angiogenin in chronic liver diseases, this study is intended to employ an ELISA in 44 pathologically proven patients. Quantikiae human angiogenin kit (R and D,systems Inc. Mmneapolis, MN) was used for this investigation. RESULTS: Mean value and standard error of angiogenin concentration (ng/ml) of the sera was 238.92+/-50.95 in 5 cases of chronic persistent hepatitis, 184.47+/-12.75 in 6 cases of chronic active hepatitis, 131.36+/-10.99 in 19 cases of liver cirrhosis, and 211.03+/-19.08 in 14 cases of hepatocellular carcinoma, respectively. Serum angiogenin level in the liver cirrhosis was significantly lower than in chronic persistent hepatitis(p=0.00336), and than in chronic active hepatitis(p=0.018673). Angiogenin concentration in hepatocellular carcinomas was significantly higher than the level of the liver cirrhosis investigated(p=0.00569). CONCLUSIONS: These data support that persistent inflammatory insults in the chronic hepatitis were compensated by the elevation of angiogenin but complete fibrosis as in liver cirrhosis showed the depressed level. And emerging of the hepatocellular carcinoma is accompanied by the elevated stimuli of angiogenin for the neovascularization.
Subject(s)
Humans , Angiogenesis Inducing Agents , Carcinoma, Hepatocellular , Enzyme-Linked Immunosorbent Assay , Fibrosis , Hand , Hepatitis, Chronic , Hypertension, Portal , Liver Cirrhosis , Liver Diseases , LiverABSTRACT
BACKGROUND/AIMS: The spectrum of clinical features of chronic liver disease bas wide range from asymptomatic cases to hepatic failure, The natural course and long-term prognosis of chronic liver disease also varies greately, and this diversity makes it diflicult to predict the clinical course of individual patient. The two majar approaches to the treatment of chronic liver disease are 1) directed toward the eradication of the virus and 2)designed to modulate cellular and humeral immunity. Progress has been made in the development of antiviral chernotherapeutic agents for hepatitis. But as yet no safe and reliably effective treatment or combination of treatrnents is available. In tkis study, we performed trial of diphenyl-dimethyl-dicarboxylate to evaluate the therapeutic effect and safety of it. METHODS: The ciinical trials of DDB(complex capsule of diphenyl dimethyl dicarboxylate 7.5mg and polysorbate 80 1,5mg and polyethylene glycol 6000 66mg) were carried out in 30 patients with chronic liver disease for 6 months. All patients had abnormal liver function test ouer a period of 6 months. RESULTS: In selected groups mean serum aspartate aminotransferase and alanine aminotrans- ferase dropped from pretreatment level of' 115.9+/-74.1 IU/L and 201.6+/-173.0 1U/L to posttreatment level of46.6+/-21.6 UU/L and 28.7+/-15.4IU/L, respectively(p<0.01). There was no significant hernatological and biochemical change after administration of DDB. Untoward side effects were easily controlled by discontinuing the drugs. CONCLUSIONS: Administration of DDB(for 6 months) appears to be effective for decrement of transaminase level and safe for the treatment of patients with chronic liver disease.
Subject(s)
Humans , Alanine , Aspartate Aminotransferases , Hepatitis , Liver Diseases , Liver Failure , Liver Function Tests , Liver , Polyethylene Glycols , Polysorbates , PrognosisABSTRACT
BACKGROUND/AIMS: Most liver diseases lead to a pathobiochemical reaction termed liver fibrosis. Hepatic fibrosis is not a uniform phenomenon and it comprises increased deposition of the liver connective tissue components(collagen, noncollagenous glycoprotein, proteoglycan) in the intercellular space, leading to disturbances of intrahepatic blood flow and hindrance of exchange processes between blood and cells, Fibrosis can be determined by morphological examination o f the liver, but this approach cannot be used to assess accurately the activity of collagen synthesis at any given point in time, Thus, the development of biochemical markers of hepatic fihrosis might allow a promising diagnostic approach for the identification and quantitation of this process, Aminoterminal procollagen III pn) peptide(PIIINP) and carboxytermina1 procollagen I propeptide(PICP) are known as the most widely used parameter for evaluating liver fibrosis, but it is diAicult to find previous report discribing the correlation ot each other. To elucidate the clinical significance of the corretation of PICP(x) and PIIINP(y) concentrations in patients with chronic liver diseases, radioimmunoassay was employed in this investigation. METHODS: Sera tested were obtained from pathologically proven 43 patients;4 cases of fatly liver, 11 cases of chronic persistent hepatitis, 13 cases of chronic active hepatitis, l5 cases of liver cirrhosis. All the patients except 4 cases ot fatty liver were shown positivity of HBsAg. PICP and PIIlNP radioimmunoassay kits(Farrnos Diagnostica, Oulunsalo, Finland) wcre purchased for this study. RESULTS: In the patients among the three groups of chronic active hepatitis, liver cirrhosis, chmnic persistent hepatitis, the correlations were significant in orders(y= - 10.27 +0.l3938x, r=0.92286, p=0.000007;y=-1.185+0.06611x, r=0.73656, p=0.001737;y=1.1174+0.03273x, r=0.56879, p=0.067849). Four cases of fatty liver reveal no signiticant correlation (y=4,8671- 0,0079x, r= 0.1959, p=0.804054). CONCLUSION: 0n the basis of these data, we s st that the correlation of each showed a significant increase with heightening degree of inflammation, activity of diseases and fibrosis.